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X-ray structure of WDR5-MLL1 Win motif peptide binary complex

X-ray diffraction
1.7Å resolution
PDB entry 4esg coloured by chain, front view.
PDB entry 4esg coloured by chain, side view.
PDB entry 4esg coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: WD repeat-containing protein 5 and MLL cleavage product C180
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Multimeric state: hetero dimer
Accessible surface area: 12424.55 Å2
Buried surface area: 1372.94 Å2
Dissociation area: 686.47 Å2
Dissociation energy (ΔGdiss): 1.44 kcal/mol
Dissociation entropy (TΔSdiss): 8.48 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158494
Assembly 2
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Assembly Name: WD repeat-containing protein 5 and MLL cleavage product C180
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Multimeric state: hetero dimer
Accessible surface area: 12429.09 Å2
Buried surface area: 1371.11 Å2
Dissociation area: 685.55 Å2
Dissociation energy (ΔGdiss): 1.8 kcal/mol
Dissociation entropy (TΔSdiss): 8.48 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158494

Macromolecules

WD repeat-containing protein 5
Chains: A, B
Length: 312 amino acids
Theoretical weight: 34.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61964 (Residues: 23-334; Coverage: 93%)
Gene names: BIG3, WDR5
Pfam: WD domain, G-beta repeat
InterPro:
CATH: YVTN repeat-like/Quinoprotein amine dehydrogenase
WD repeat-containing protein 5 in PDB entry 4esg, assembly 1, front view.
WD repeat-containing protein 5 in PDB entry 4esg, assembly 1, side view.
WD repeat-containing protein 5 in PDB entry 4esg, assembly 1, top view.
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MLL cleavage product C180
Chains: C, D
Length: 17 amino acids
Theoretical weight: 1.88 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q03164 (Residues: 3755-3771; Coverage: 0%)
Gene names: ALL1, CXXC7, HRX, HTRX, KMT2A, MLL, MLL1, TRX1
MLL cleavage product C180 in PDB entry 4esg, assembly 1, front view.
MLL cleavage product C180 in PDB entry 4esg, assembly 1, side view.
MLL cleavage product C180 in PDB entry 4esg, assembly 1, top view.
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