PDBe 4erk

X-ray diffraction
2.2Å resolution

THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/OLOMOUCINE

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 364 amino acids
Theoretical weight: 42.16 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P63086 (Residues: 1-358; Coverage: 100%)
Gene names: Erk2, Mapk, Mapk1, Prkm1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P21
Unit cell:
a: 48.87Å b: 70.26Å c: 59.97Å
α: 90° β: 109.05° γ: 90°
R-values:
R R work R free
0.214 0.214 0.317
Expression system: Escherichia coli BL21(DE3)