PDBe 4eph

X-ray diffraction
2.3Å resolution

CRYSTAL STRUCTURE OF RAT CARNITINE PALMITOYLTRANSFERASE 2 IN COMPLEX with CoA-site inhibitor

Released:

Function and Biology Details

Reaction catalysed:
Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carnitine O-palmitoyltransferase 2, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 653 amino acids
Theoretical weight: 73.57 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P18886 (Residues: 27-658; Coverage: 96%)
Gene names: Cpt-2, Cpt2
Sequence domains: Choline/Carnitine o-acyltransferase

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P43212
Unit cell:
a: 67.64Å b: 67.64Å c: 309.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.186 0.249
Expression system: Escherichia coli BL21(DE3)