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Crystal structure of the TIR domain of human myeloid differentiation primary response protein 88.

Source organism: Homo sapiens
Biochemical function: TIR domain binding
Biological process: positive regulation of canonical NF-kappaB signal transduction
Cellular component: not assigned

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF13676
Domain description: TIR domain
Occurring in:
  1. Myeloid differentiation primary response protein MyD88
The deposited structure of PDB entry 4eo7 contains 1 copy of Pfam domain PF13676 (TIR domain) in Myeloid differentiation primary response protein MyD88. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000157
Domain description: Toll/interleukin-1 receptor homology (TIR) domain
Occurring in:
  1. Myeloid differentiation primary response protein MyD88
IPR035897
Domain description: Toll/interleukin-1 receptor homology (TIR) domain superfamily
Occurring in:
  1. Myeloid differentiation primary response protein MyD88
IPR017281
Domain description: Myeloid differentiation primary response protein MyD88
Occurring in:
  1. Myeloid differentiation primary response protein MyD88

Structure domain

CATH CATH domain
3.40.50.10140
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Toll/interleukin-1 receptor homology (TIR) domain
Occurring in:
  1. Myeloid differentiation primary response protein MyD88
The deposited structure of PDB entry 4eo7 contains 1 copy of CATH domain 3.40.50.10140 (Rossmann fold) in Myeloid differentiation primary response protein MyD88. Showing 1 copy in chain A.

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