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Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with DADMe-ImmG and phosphate

X-ray diffraction
2.3Å resolution
PDB entry 4eb8 coloured by chain, front view.
PDB entry 4eb8 coloured by chain, side view.
PDB entry 4eb8 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Purine nucleoside phosphorylase
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Multimeric state: homo trimer
Accessible surface area: 30826.34 Å2
Buried surface area: 9448.88 Å2
Dissociation area: 4,230.68 Å2
Dissociation energy (ΔGdiss): 30.15 kcal/mol
Dissociation entropy (TΔSdiss): 27.8 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-132560

Macromolecules

Purine nucleoside phosphorylase
Chains: A, B, C
Length: 324 amino acids
Theoretical weight: 36.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00491 (Residues: 1-289; Coverage: 100%)
Gene names: NP, PNP
Pfam: Phosphorylase superfamily
InterPro:
CATH: Nucleoside phosphorylase domain
Purine nucleoside phosphorylase in PDB entry 4eb8, assembly 1, front view.
Purine nucleoside phosphorylase in PDB entry 4eb8, assembly 1, side view.
Purine nucleoside phosphorylase in PDB entry 4eb8, assembly 1, top view.
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