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Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4

X-ray diffraction
2.6Å resolution
PDB entry 4e41 coloured by chain, front view.
PDB entry 4e41 coloured by chain, side view.
PDB entry 4e41 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 35603.97 Å2
Buried surface area: 13756.8 Å2
Dissociation area: 1,181.78 Å2
Dissociation energy (ΔGdiss): -2.78 kcal/mol
Dissociation entropy (TΔSdiss): 13.84 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-208755
Assembly 2
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Multimeric state: hetero pentamer
Accessible surface area: 35318.84 Å2
Buried surface area: 13674.78 Å2
Dissociation area: 1,178.85 Å2
Dissociation energy (ΔGdiss): -3.21 kcal/mol
Dissociation entropy (TΔSdiss): 13.84 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-208755

Macromolecules

HLA class II histocompatibility antigen, DR alpha chain
Chains: A, F
Length: 182 amino acids
Theoretical weight: 21.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01903 (Residues: 26-207; Coverage: 80%)
Gene names: HLA-DRA, HLA-DRA1
Pfam:
InterPro:
CATH:
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 4e41, assembly 1, front view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 4e41, assembly 1, side view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 4e41, assembly 1, top view.
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HLA class II histocompatibility antigen, DRB1 beta chain
Chains: B, G
Length: 190 amino acids
Theoretical weight: 22.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01911 (Residues: 30-219; Coverage: 80%)
Gene name: HLA-DRB1
Pfam:
InterPro:
CATH:
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 4e41, assembly 1, front view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 4e41, assembly 1, side view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 4e41, assembly 1, top view.
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Triosephosphate isomerase
Chains: C, H
Length: 15 amino acids
Theoretical weight: 1.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P60174 (Residues: 23-37; Coverage: 6%)
Gene names: TPI, TPI1
Triosephosphate isomerase in PDB entry 4e41, assembly 1, front view.
Triosephosphate isomerase in PDB entry 4e41, assembly 1, side view.
Triosephosphate isomerase in PDB entry 4e41, assembly 1, top view.
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T cell receptor G4 alpha chain
Chains: D, I
Length: 203 amino acids
Theoretical weight: 22.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
CATH: Immunoglobulins
T cell receptor G4 alpha chain in PDB entry 4e41, assembly 1, front view.
T cell receptor G4 alpha chain in PDB entry 4e41, assembly 1, side view.
T cell receptor G4 alpha chain in PDB entry 4e41, assembly 1, top view.
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T cell receptor G4 beta chain
Chains: E, J
Length: 239 amino acids
Theoretical weight: 27.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
CATH: Immunoglobulins
T cell receptor G4 beta chain in PDB entry 4e41, assembly 1, front view.
T cell receptor G4 beta chain in PDB entry 4e41, assembly 1, side view.
T cell receptor G4 beta chain in PDB entry 4e41, assembly 1, top view.
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