PDBe 4e1z

X-ray diffraction
2.5Å resolution

Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Non-receptor tyrosine-protein kinase TYK2 Chain: A
Molecule details ›
Chain: A
Length: 291 amino acids
Theoretical weight: 33.7 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9R117 (Residues: 880-1170; Coverage: 25%)
Gene name: Tyk2
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: P3121
Unit cell:
a: 68.03Å b: 68.03Å c: 152.999Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.197 0.237
Expression system: Spodoptera frugiperda