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Crystal structure of a Peptidyl-prolyl cis-trans isomerase with surface mutation R92G from Burkholderia pseudomallei complexed with FK506

X-ray diffraction
2Å resolution
PDB entry 4dz2 coloured by chain, front view.
PDB entry 4dz2 coloured by chain, side view.
PDB entry 4dz2 coloured by chain, top view.
Source organism: Burkholderia pseudomallei 1710b
Assemblies composition:
homo dimer (preferred)
homo tetramer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Peptidyl-prolyl cis-trans isomerase
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Multimeric state: homo dimer
Accessible surface area: 11545.64 Å2
Buried surface area: 2330.22 Å2
Dissociation area: 271.7 Å2
Dissociation energy (ΔGdiss): 2.35 kcal/mol
Dissociation entropy (TΔSdiss): 10.98 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-174637
Assembly 2
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Assembly Name: Peptidyl-prolyl cis-trans isomerase
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Multimeric state: homo dimer
Accessible surface area: 11605.09 Å2
Buried surface area: 2323.2 Å2
Dissociation area: 269.89 Å2
Dissociation energy (ΔGdiss): 2.3 kcal/mol
Dissociation entropy (TΔSdiss): 11 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-174637
Assembly 3
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Assembly Name: Peptidyl-prolyl cis-trans isomerase
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Multimeric state: homo tetramer
Accessible surface area: 20483.88 Å2
Buried surface area: 7320.28 Å2
Dissociation area: 1,877.87 Å2
Dissociation energy (ΔGdiss): 10.21 kcal/mol
Dissociation entropy (TΔSdiss): 34.88 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-174638

Macromolecules

Peptidyl-prolyl cis-trans isomerase
Chains: A, B
Length: 113 amino acids
Theoretical weight: 11.8 KDa
Source organism: Burkholderia pseudomallei 1710b
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q3JK38 (Residues: 2-113; Coverage: 99%)
Gene name: BURPS1710b_A0907
Pfam: FKBP-type peptidyl-prolyl cis-trans isomerase
InterPro:
CATH: Chitinase A; domain 3
Peptidyl-prolyl cis-trans isomerase in PDB entry 4dz2, assembly 1, front view.
Peptidyl-prolyl cis-trans isomerase in PDB entry 4dz2, assembly 1, side view.
Peptidyl-prolyl cis-trans isomerase in PDB entry 4dz2, assembly 1, top view.
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