› 4dn8

X-ray diffraction
2.2Å resolution

Structure of porcine surfactant protein D neck and carbohydrate recognition domain complexed with mannose

Released:
DOI: 10.2210/pdb4dn8/pdb
PDB entry 4dn8 coloured by chain, front view.
PDB entry 4dn8 coloured by chain, side view.
PDB entry 4dn8 coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
A unique sugar-binding site mediates the distinct anti-influenza activity of pig surfactant protein D.
van Eijk M, Rynkiewicz MJ, White MR, Hartshorn KL, Zou X, Schulten K, Luo D, Crouch EC, Cafarella TR, Head JF, Haagsman HP, Seaton BA
J Biol Chem 287 26666-77 (2012)
PMID: 22685299

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192404 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pulmonary surfactant-associated protein D Chain: A
Molecule details ›
Chain: A
Length: 156 amino acids
Theoretical weight: 17.06 KDa
Source organism: Sus scrofa
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9N1X4 (Residues: 223-378; Coverage: 44%)
Gene name: SFTPD
Sequence domains:
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

2 bound ligands:
Ligand CA 2 x CA
Ligand BMA 1 x BMA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P63
Unit cell:
a: 66.024Å b: 66.024Å c: 66.018Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.203 0.199 0.237
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Emerging antiviral strategies to interfere with influenza virus entry.
Vanderlinden et al. (2014)
4 more

6 mentions without citation

Integrated Omics and Computational Glycobiology Reveal Structural Basis for Influenza A Virus Glycan Microheterogeneity and Host Interactions.
Khatri et al. (2016)
5 more