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Human DNA polymerase eta inserting dCMPNPP opposite the 5'G of cisplatin crosslinked Gs (Pt-GG2).

X-ray diffraction
2.92Å resolution
PDB entry 4dl5 coloured by chain, front view.
PDB entry 4dl5 coloured by chain, side view.
PDB entry 4dl5 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: DNA polymerase eta and DNA
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Multimeric state: hetero trimer
Accessible surface area: 21319.26 Å2
Buried surface area: 3788.15 Å2
Dissociation area: 1,006.98 Å2
Dissociation energy (ΔGdiss): 24.56 kcal/mol
Dissociation entropy (TΔSdiss): 9.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-117326

Macromolecules

DNA polymerase eta
Chain: A
Length: 435 amino acids
Theoretical weight: 48.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y253 (Residues: 1-432; Coverage: 61%)
Gene names: POLH, RAD30, RAD30A, XPV
Pfam:
InterPro:
CATH:
DNA polymerase eta in PDB entry 4dl5, assembly 1, front view.
DNA polymerase eta in PDB entry 4dl5, assembly 1, side view.
DNA polymerase eta in PDB entry 4dl5, assembly 1, top view.
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DNA chain T
Name: DNA (5'-D(*TP*AP*CP*GP*GP*TP*CP*AP*CP*AP*CP*T)-3')
Representative chains: T
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 12 nucleotides
Theoretical weight: 3.62 KDa
DNA (5'-D(*TP*AP*CP*GP*GP*TP*CP*AP*CP*AP*CP*T)-3') in PDB entry 4dl5, assembly 1, front view.
DNA (5'-D(*TP*AP*CP*GP*GP*TP*CP*AP*CP*AP*CP*T)-3') in PDB entry 4dl5, assembly 1, side view.
DNA (5'-D(*TP*AP*CP*GP*GP*TP*CP*AP*CP*AP*CP*T)-3') in PDB entry 4dl5, assembly 1, top view.
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DNA chain P
Name: DNA (5'-D(P*TP*AP*GP*TP*GP*TP*GP*AP*C)-3')
Representative chains: P
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 9 nucleotides
Theoretical weight: 2.77 KDa
DNA (5'-D(P*TP*AP*GP*TP*GP*TP*GP*AP*C)-3') in PDB entry 4dl5, assembly 1, front view.
DNA (5'-D(P*TP*AP*GP*TP*GP*TP*GP*AP*C)-3') in PDB entry 4dl5, assembly 1, side view.
DNA (5'-D(P*TP*AP*GP*TP*GP*TP*GP*AP*C)-3') in PDB entry 4dl5, assembly 1, top view.
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