PDBe 4dgc

X-ray diffraction
2.65Å resolution

TRIMCyp cyclophilin domain from Macaca mulatta: cyclosporin A complex


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase A Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 165 amino acids
Theoretical weight: 18.02 KDa
Source organism: Macaca mulatta
Expression system: Escherichia coli
  • Canonical: P62940 (Residues: 1-165; Coverage: 100%)
Gene names: CYPA, PPIA
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like
cyclosporin A Chains: F, G, H, I, J
Molecule details ›
Chains: F, G, H, I, J
Length: 11 amino acids
Theoretical weight: 1.22 KDa
Source organism: Tolypocladium inflatum
Expression system: Not provided

Ligands and Environments

No bound ligands

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P6122
Unit cell:
a: 108.47Å b: 108.47Å c: 423.06Å
α: 90° β: 90° γ: 120°
R R work R free
0.184 0.182 0.216
Expression systems:
  • Escherichia coli
  • Not provided