PDBe 4cyh

X-ray diffraction
2.1Å resolution

CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE HIS-PRO

Released:
Source organism: Homo sapiens
Primary publication:
Mechanistic implication of crystal structures of the cyclophilin-dipeptide complexes.
Biochemistry 35 7362-8 (1996)
PMID: 8652512

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase A Chain: A
Molecule details ›
Chain: A
Length: 164 amino acids
Theoretical weight: 17.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62937 (Residues: 2-165; Coverage: 99%)
Gene names: CYPA, PPIA
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 40.7Å b: 52.4Å c: 89.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.185 not available
Expression system: Escherichia coli