PDBe 4cy2

X-ray diffraction
2Å resolution

Crystal structure of the KANSL1-WDR5-KANSL2 complex.

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
WD repeat-containing protein 5 Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 34.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61964 (Residues: 23-334; Coverage: 93%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
KAT8 regulatory NSL complex subunit 2 Chain: C
Molecule details ›
Chain: C
Length: 13 amino acids
Theoretical weight: 1.43 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9H9L4 (Residues: 406-417; Coverage: 2%)
Gene names: C12orf41, KANSL2, NSL2
KAT8 regulatory NSL complex subunit 1 Chain: D
Molecule details ›
Chain: D
Length: 15 amino acids
Theoretical weight: 1.61 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q7Z3B3 (Residues: 585-598; Coverage: 1%)
Gene names: CENP-36, KANSL1, KIAA1267, MSL1V1, NSL1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P21212
Unit cell:
a: 81.59Å b: 86.6Å c: 45.08Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.199 0.222
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided