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Human Notch1 EGF domains 11-13 mutant fucosylated at T466

X-ray diffraction
1.85Å resolution
PDB entry 4cud coloured by chain, front view.
PDB entry 4cud coloured by chain, side view.
PDB entry 4cud coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Neurogenic locus notch homolog protein 1
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Multimeric state: homo dimer
Accessible surface area: 15155.45 Å2
Buried surface area: 2170.18 Å2
Dissociation area: 758.57 Å2
Dissociation energy (ΔGdiss): 10.2 kcal/mol
Dissociation entropy (TΔSdiss): 12.15 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-155484

Macromolecules

Neurogenic locus notch homolog protein 1
Chain: A
Length: 135 amino acids
Theoretical weight: 14.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P46531 (Residues: 410-526; Coverage: 5%)
Gene names: NOTCH1, TAN1
Pfam:
InterPro:
CATH: Laminin
Neurogenic locus notch homolog protein 1 in PDB entry 4cud, assembly 1, front view.
Neurogenic locus notch homolog protein 1 in PDB entry 4cud, assembly 1, side view.
Neurogenic locus notch homolog protein 1 in PDB entry 4cud, assembly 1, top view.
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