PDBe 4cmv

X-ray diffraction
2.31Å resolution

Function and Biology Details

Reactions catalysed:
Tuberculosinyl diphosphate + H(2)O = (13S)-isotuberculosinol + diphosphate
Tuberculosinyl diphosphate + H(2)O = tuberculosinol + diphosphate
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Diterpene synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 296 amino acids
Theoretical weight: 34.07 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WJ60 (Residues: 1-296; Coverage: 100%)
Gene name: MT3488
Structure domains: Decaprenyl diphosphate synthase-like

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P212121
Unit cell:
a: 57.705Å b: 94.983Å c: 111.161Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.188 0.229
Expression system: Escherichia coli BL21(DE3)