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X-RAY ANALYSES OF ASPARTIC PROTEINASES IV. STRUCTURE AND REFINEMENT AT 2.2 ANGSTROMS RESOLUTION OF BOVINE CHYMOSIN

Source organism: Bos taurus
Biochemical function: aspartic-type endopeptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.23.4: Chymosin

Reaction catalysed:
Broad specificity similar to that of pepsin A. Clots milk by cleavage of a single 104-Ser-Phe-|-Met-Ala-107 bond in kappa-chain of casein.
Systematic name:
-
Alternative Name(s):
  • Rennin
  • Rennin (but this should be avoided since it leads to confusion with renin)

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00026
Domain description: Eukaryotic aspartyl protease
Occurring in:
  1. Chymosin
The deposited structure of PDB entry 4cms contains 1 copy of Pfam domain PF00026 (Eukaryotic aspartyl protease) in Chymosin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001461
Domain description: Aspartic peptidase A1 family
Occurring in:
  1. Chymosin
IPR021109
Domain description: Aspartic peptidase domain superfamily
Occurring in:
  1. Chymosin
IPR001969
Domain description: Aspartic peptidase, active site
Occurring in:
  1. Chymosin
IPR033121
Domain description: Peptidase family A1 domain
Occurring in:
  1. Chymosin
IPR034162
Domain description: Pepsin catalytic domain
Occurring in:
  1. Chymosin

Structure domain

CATH CATH domain
2.40.70.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Cathepsin D, subunit A; domain 1
Homology: Acid Proteases
Occurring in:
  1. Chymosin
The deposited structure of PDB entry 4cms contains 2 copies of CATH domain 2.40.70.10 (Cathepsin D, subunit A; domain 1) in Chymosin. Showing 2 copies in chain A.
SCOP SCOP annotation
50646
Class: All beta proteins
Fold: Acid proteases
Superfamily: Acid proteases
Occurring in:
  1. Chymosin
The deposited structure of PDB entry 4cms contains 1 copy of SCOP domain 50646 (Pepsin-like) in Chymosin. Showing 1 copy in chain A.

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