› › Structure analysis

Human DPP1 in complex with (2S)-N-((1S)-1-cyano-2-(4-(4-cyanophenyl) phenyl)ethyl)piperidine-2-carboxamide

X-ray diffraction
2.35Å resolution
PDB entry 4cdd coloured by chain, front view.
PDB entry 4cdd coloured by chain, side view.
PDB entry 4cdd coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1
Download    3D Visualisation
Assembly Name: Dipeptidyl peptidase 1 heavy chain
hide full assembly name
Multimeric state: hetero trimer
Accessible surface area: 14961.84 Å2
Buried surface area: 8748.63 Å2
Dissociation area: 1,249.64 Å2
Dissociation energy (ΔGdiss): 9.35 kcal/mol
Dissociation entropy (TΔSdiss): 11.77 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156841
Assembly 2 (preferred)
Download    3D Visualisation
Assembly Name: Dipeptidyl peptidase 1 heavy chain
hide full assembly name
Multimeric state: hetero trimer
Accessible surface area: 15798.64 Å2
Buried surface area: 9505.96 Å2
Dissociation area: 1,322.26 Å2
Dissociation energy (ΔGdiss): 9.41 kcal/mol
Dissociation entropy (TΔSdiss): 11.95 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156841

Macromolecules

Dipeptidyl peptidase 1 exclusion domain chain
Chains: A, D
Length: 120 amino acids
Theoretical weight: 13.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53634 (Residues: 25-144; Coverage: 27%)
Gene names: CPPI, CTSC
Pfam: Cathepsin C exclusion domain
InterPro:
CATH: Cathepsin C, exclusion domain
Dipeptidyl peptidase 1 exclusion domain chain in PDB entry 4cdd, assembly 2, front view.
Dipeptidyl peptidase 1 exclusion domain chain in PDB entry 4cdd, assembly 2, side view.
Dipeptidyl peptidase 1 exclusion domain chain in PDB entry 4cdd, assembly 2, top view.
Molecule details ›

Search similar proteins

Dipeptidyl peptidase 1 heavy chain
Chains: B, E
Length: 165 amino acids
Theoretical weight: 18.63 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53634 (Residues: 230-394; Coverage: 38%)
Gene names: CPPI, CTSC
Pfam: Papain family cysteine protease
InterPro:
CATH: Cysteine proteinases
Dipeptidyl peptidase 1 heavy chain in PDB entry 4cdd, assembly 2, front view.
Dipeptidyl peptidase 1 heavy chain in PDB entry 4cdd, assembly 2, side view.
Dipeptidyl peptidase 1 heavy chain in PDB entry 4cdd, assembly 2, top view.
Molecule details ›

Search similar proteins

Dipeptidyl peptidase 1 light chain
Chains: C, F
Length: 69 amino acids
Theoretical weight: 7.58 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53634 (Residues: 395-463; Coverage: 16%)
Gene names: CPPI, CTSC
InterPro:
CATH: Cysteine proteinases. Chain C
Dipeptidyl peptidase 1 light chain in PDB entry 4cdd, assembly 2, front view.
Dipeptidyl peptidase 1 light chain in PDB entry 4cdd, assembly 2, side view.
Dipeptidyl peptidase 1 light chain in PDB entry 4cdd, assembly 2, top view.
Molecule details ›

Search similar proteins

Quick links