Function and Biology

SIR2 COMPLEX STRUCTURE MIXTURE OF EX-527 INHIBITOR AND REACTION PRODUCTS OR OF REACTION SUBSTRATES P53 PEPTIDE AND NAD

Source organisms:
Biochemical function: NAD-dependent protein deacetylase activity
Biological process: protein deacetylation
Cellular component: cytoplasm

Sequence family

Pfam Protein family (Pfam)
PF02146
Domain description: Sir2 family
Occurring in:
  1. NAD-dependent protein deacetylase
1 copy of Pfam domain PF02146 (Sir2 family) in NAD-dependent protein deacetylase in PDB 4buz.

InterPro InterPro annotations
IPR029035
Domain description: DHS-like NAD/FAD-binding domain superfamily
Occurring in:
  1. NAD-dependent protein deacetylase
IPR026591
Domain description: Sirtuin, catalytic core small domain superfamily
Occurring in:
  1. NAD-dependent protein deacetylase
IPR003000
Domain description: Sirtuin family
Occurring in:
  1. NAD-dependent protein deacetylase
IPR026590
Domain description: Sirtuin family, catalytic core domain
Occurring in:
  1. NAD-dependent protein deacetylase
IPR028628
Domain description: Sirtuin, class U
Occurring in:
  1. NAD-dependent protein deacetylase

Structure domain

CATH CATH domain
3.30.1600.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: SIR2/SIRT2 'Small Domain'
Homology: SIR2/SIRT2 'Small Domain'
Occurring in:
  1. NAD-dependent protein deacetylase
1 copy of CATH domain 3.30.1600.10 (SIR2/SIRT2 'Small Domain') in NAD-dependent protein deacetylase in PDB 4buz.