Function and Biology

Scaffold Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitor

Source organism: Homo sapiens
Biochemical function: ATP binding
Biological process: protein phosphorylation
Cellular component: not assigned

EC 2.7.12.1: Dual-specificity kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein.
Comments:
  • This family of enzymes can phosphorylate both Ser/Thr and Tyr residues.
  • Formerly EC 2.7.1.37.
Systematic name:
ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating)
Alternative Name(s):
  • ADK1
  • Arabidopsis dual specificity kinase 1
  • CLK1
  • DDYRK2
  • Mps1p

Sequence family

Pfam Protein family (Pfam)
PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Dual specificity protein kinase TTK
1 copy of Pfam domain PF00069 (Protein kinase domain) in Dual specificity protein kinase TTK in PDB 4bi0.

InterPro InterPro annotations
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. Dual specificity protein kinase TTK
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Dual specificity protein kinase TTK
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. Dual specificity protein kinase TTK
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Dual specificity protein kinase TTK
IPR027084
Domain description: Protein kinase Mps1 family
Occurring in:
  1. Dual specificity protein kinase TTK

Structure domains

CATH CATH domains
1.10.510.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase(Phosphotransferase); domain 1
Homology: Transferase(Phosphotransferase) domain 1
Occurring in:
  1. Dual specificity protein kinase TTK
1 copy of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in Dual specificity protein kinase TTK in PDB 4bi0.
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Dual specificity protein kinase TTK
1 copy of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Dual specificity protein kinase TTK in PDB 4bi0.