› 4bfe

X-ray diffraction
2.5Å resolution

Structure of the extracellular portion of mouse CD200RLa

Released:
DOI: 10.2210/pdb4bfe/pdb
PDB entry 4bfe coloured by chain, front view.
PDB entry 4bfe coloured by chain, side view.
PDB entry 4bfe coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structures of CD200/CD200 receptor family and implications for topology, regulation, and evolution.
Hatherley D, Lea SM, Johnson S, Barclay AN
Structure 21 820-32 (2013)
PMID: 23602662

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180529 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cell surface glycoprotein CD200 receptor 4 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 221 amino acids
Theoretical weight: 24.34 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q6XJV4 (Residues: 26-238; Coverage: 87%)
Gene name: Cd200r4
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

4 bound ligands:
Ligand NAG 15 x NAG
Ligand CYS 3 x CYS
Ligand SO4 7 x SO4
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P6522
Unit cell:
a: 157.59Å b: 157.59Å c: 167.94Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.173 0.171 0.205
Expression system: Cricetulus griseus

Quick links

Citations

16 review citations

The interaction between signal regulatory protein alpha (SIRPĪ±) and CD47: structure, function, and therapeutic target.
Barclay et al. (2014)
15 more