EC 2.4.2.30: NAD(+) ADP-ribosyltransferase
Reaction catalysed:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Systematic name:
NAD(+):poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
Alternative Name(s):
- ADP-ribosyltransferase (polymerizing)
- NAD(+):poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
- NAD(+):poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
- Poly(ADP-ribose) synthase
- Poly(ADP-ribose) synthetase
- Poly(ADP-ribose)polymerase
- Poly(adenosine diphosphate ribose) polymerase
GO terms
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Protein family (Pfam)![The deposited structure of PDB entry 4av1 contains 8 copies of Pfam domain PF00645 (Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region) in Poly [ADP-ribose] polymerase 1, processed N-terminus. Showing 2 copies in chain B (some of the copies are out of the observed residue ranges!).](https://www.ebi.ac.uk/pdbe/static/entry/4av1_1_B_Pfam_PF00645_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4av1</span> contains 8 copies of Pfam domain <span class='highlight'>PF00645 (Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region)</span> in <span class='highlight'>Poly [ADP-ribose] polymerase 1, processed N-terminus</span>. Showing 2 copies in chain <span class='highlight'>B</span> (some of the copies are out of the observed residue ranges!).")
InterPro annotations
CATH domain![The deposited structure of PDB entry 4av1 contains 4 copies of CATH domain 3.30.1740.10 (first zn-finger domain of poly(adp-ribose) polymerase-1) in Poly [ADP-ribose] polymerase 1, processed N-terminus. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/4av1_1_B_CATH_3.30.1740.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4av1</span> contains 4 copies of CATH domain <span class='highlight'>3.30.1740.10 (first zn-finger domain of poly(adp-ribose) polymerase-1)</span> in <span class='highlight'>Poly [ADP-ribose] polymerase 1, processed N-terminus</span>. Showing 1 copy in chain <span class='highlight'>B</span>.")