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Ligand controlled assembly of hexamers, dihexamers, and linear multihexamer structures by an engineered acylated insulin

X-ray diffraction
1.8Å resolution
PDB entry 4ajz coloured by chain, front view.
PDB entry 4ajz coloured by chain, side view.
PDB entry 4ajz coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero hexamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Insulin A chain
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Multimeric state: hetero hexamer
Accessible surface area: 10096.78 Å2
Buried surface area: 4976.95 Å2
Dissociation area: 208.65 Å2
Dissociation energy (ΔGdiss): 20.93 kcal/mol
Dissociation entropy (TΔSdiss): 18.86 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134224
Assembly 2 (preferred)
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Assembly Name: Insulin A chain
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Multimeric state: hetero hexamer
Accessible surface area: 9768.59 Å2
Buried surface area: 6485.57 Å2
Dissociation area: 1,070.16 Å2
Dissociation energy (ΔGdiss): 20.43 kcal/mol
Dissociation entropy (TΔSdiss): 20.49 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134224

Macromolecules

Insulin A chain
Chains: A, C
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
InterPro:
Insulin A chain in PDB entry 4ajz, assembly 2, front view.
Insulin A chain in PDB entry 4ajz, assembly 2, side view.
Insulin A chain in PDB entry 4ajz, assembly 2, top view.
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Insulin B chain
Chains: B, D
Length: 29 amino acids
Theoretical weight: 3.33 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P01308 (Residues: 25-53; Coverage: 34%)
Gene name: INS
Pfam: Insulin/IGF/Relaxin family
InterPro:
Insulin B chain in PDB entry 4ajz, assembly 2, front view.
Insulin B chain in PDB entry 4ajz, assembly 2, side view.
Insulin B chain in PDB entry 4ajz, assembly 2, top view.
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