Structure analysis

HLA-DR1 with covalently linked CLIP106-120 in reversed orientation

X-ray diffraction
2.2Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 17900 Å2
Buried surface area: 7500 Å2
Dissociation area: 3,000 Å2
Dissociation energy (ΔGdiss): 43 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -44 kcal/mol
Symmetry number: 1

Macromolecules

Chain: C
Length: 16 amino acids
Theoretical weight: 1.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04233 (Residues: 106-120; Coverage: 5%)
Gene names: CD74, DHLAG

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