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Crystal structure of ANCE in complex with Angiotensin-II

X-ray diffraction
1.99Å resolution
PDB entry 4aa1 coloured by chain, front view.
PDB entry 4aa1 coloured by chain, side view.
PDB entry 4aa1 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Angiotensin-converting enzyme and Angiotensin-1
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Multimeric state: hetero dimer
Accessible surface area: 25061.32 Å2
Buried surface area: 2668.62 Å2
Dissociation area: 547.79 Å2
Dissociation energy (ΔGdiss): 21.64 kcal/mol
Dissociation entropy (TΔSdiss): 5.65 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133814

Macromolecules

Angiotensin-converting enzyme
Chain: A
Length: 598 amino acids
Theoretical weight: 69.15 KDa
Source organism: Drosophila melanogaster
Expression system: Komagataella phaffii GS115
UniProt:
  • Canonical: Q10714 (Residues: 17-614; Coverage: 100%)
Gene names: Ance, CG8827, Race
Pfam: Angiotensin-converting enzyme
InterPro: Peptidase M2, peptidyl-dipeptidase A
Angiotensin-converting enzyme in PDB entry 4aa1, assembly 1, front view.
Angiotensin-converting enzyme in PDB entry 4aa1, assembly 1, side view.
Angiotensin-converting enzyme in PDB entry 4aa1, assembly 1, top view.
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Angiotensin-2
Chain: P
Length: 8 amino acids
Theoretical weight: 1.05 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01019 (Residues: 25-32; Coverage: 2%)
Gene names: AGT, SERPINA8
Angiotensin-1 in PDB entry 4aa1, assembly 1, front view.
Angiotensin-1 in PDB entry 4aa1, assembly 1, side view.
Angiotensin-1 in PDB entry 4aa1, assembly 1, top view.
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