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Symmetric Dimethylation of H3 Arginine 2 is a Novel Histone Mark that Supports Euchromatin Maintenance

X-ray diffraction
1.9Å resolution
PDB entry 4a7j coloured by chain, front view.
PDB entry 4a7j coloured by chain, side view.
PDB entry 4a7j coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: WD repeat-containing protein 5 and Histone H3.1
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Multimeric state: hetero dimer
Accessible surface area: 11881.27 Å2
Buried surface area: 1123.66 Å2
Dissociation area: 561.83 Å2
Dissociation energy (ΔGdiss): 4.33 kcal/mol
Dissociation entropy (TΔSdiss): 6.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158475

Macromolecules

WD repeat-containing protein 5
Chain: A
Length: 318 amino acids
Theoretical weight: 34.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P61964 (Residues: 21-334; Coverage: 94%)
Gene names: BIG3, WDR5
Pfam: WD domain, G-beta repeat
InterPro:
CATH: YVTN repeat-like/Quinoprotein amine dehydrogenase
WD repeat-containing protein 5 in PDB entry 4a7j, assembly 1, front view.
WD repeat-containing protein 5 in PDB entry 4a7j, assembly 1, side view.
WD repeat-containing protein 5 in PDB entry 4a7j, assembly 1, top view.
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Histone H3.1
Chain: B
Length: 16 amino acids
Theoretical weight: 1.72 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P68431 (Residues: 1-16; Coverage: 12%)
Gene names: H3C1, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3FA, H3FB, H3FC HIST1H3C, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J
Histone H3.1 in PDB entry 4a7j, assembly 1, front view.
Histone H3.1 in PDB entry 4a7j, assembly 1, side view.
Histone H3.1 in PDB entry 4a7j, assembly 1, top view.
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