PDBe 4a69

X-ray diffraction
2.06Å resolution

Structure of HDAC3 bound to corepressor and inositol tetraphosphate

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone deacetylase 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 376 amino acids
Theoretical weight: 42.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O15379 (Residues: 1-376; Coverage: 88%)
Gene name: HDAC3
Sequence domains: Histone deacetylase domain
Structure domains: Histone deacetylase domain
Nuclear receptor corepressor 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 94 amino acids
Theoretical weight: 11.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9Y618 (Residues: 389-480; Coverage: 4%)
Gene names: CTG26, NCOR2
Structure domains: Homeodomain-like

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: C2221
Unit cell:
a: 86.447Å b: 118.634Å c: 190.707Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.187 0.236
Expression system: Homo sapiens