PDBe 4zzj

X-ray diffraction
2.74Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
SirtT1 75 kDa fragment Chain: A
Molecule details ›
Chain: A
Length: 356 amino acids
Theoretical weight: 40.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96EB6 (Residues: 183-505; Coverage: 43%)
Gene names: SIR2L1, SIRT1
Sequence domains: Sir2 family
Cellular tumor antigen p53 Chain: B
Molecule details ›
Chain: B
Length: 7 amino acids
Theoretical weight: 986 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04637 (Residues: 379-385; Coverage: 2%)
  • Best match: P04637-9 (Residues: 81-82)
Gene names: P53, TP53

Ligands and Environments


2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: I4122
Unit cell:
a: 94.51Å b: 94.51Å c: 356.84Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.182 0.221
Expression systems:
  • Escherichia coli
  • Not provided