PDBe 4zte

X-ray diffraction
2.13Å resolution

Crystal structure of human E-Cadherin (residues 3-213) in complex with a peptidomimetic inhibitor

Released:

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 211 amino acids
Theoretical weight: 22.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12830 (Residues: 157-367; Coverage: 25%)
Gene names: CDH1, CDHE, UVO
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: C2
Unit cell:
a: 120.579Å b: 76.835Å c: 72.772Å
α: 90° β: 111.14° γ: 90°
R-values:
R R work R free
0.187 0.185 0.23
Expression system: Escherichia coli BL21(DE3)