› 4zse

X-ray diffraction
1.97Å resolution

Crystal structure of EGFR 696-1022 T790M/V948R, crystal form II

Released:
DOI: 10.2210/pdb4zse/pdb
PDB entry 4zse coloured by chain, front view.
PDB entry 4zse coloured by chain, side view.
PDB entry 4zse coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Yan XE, Yun CH

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132701 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor receptor Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 331 amino acids
Theoretical weight: 37.72 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00533 (Residues: 695-1022; Coverage: 28%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand ANP 4 x ANP
Ligand MG 4 x MG
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: P21
Unit cell:
a: 71.82Å b: 102.317Å c: 86.752Å
α: 90° β: 101.24° γ: 90°
R-values:
R R work R free
0.191 0.19 0.213
Expression system: Spodoptera frugiperda

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