PDBe 4zjv

X-ray diffraction
2.7Å resolution

crystal structure of EGFR kinase domain in complex with Mitogen-inducible gene 6 protein


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Epidermal growth factor receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 331 amino acids
Theoretical weight: 37.64 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: NEW P00533 (Residues: 695-1022; Coverage: 28%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains: Protein tyrosine kinase
Structure domains:
ERBB receptor feedback inhibitor 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 70 amino acids
Theoretical weight: 7.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: NEW Q9UJM3 (Residues: 330-399; Coverage: 15%)
Gene names: ERRFI1, MIG6

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 58.459Å b: 81.865Å c: 96.19Å
α: 90° β: 106.67° γ: 90°
R R work R free
0.181 0.179 0.232
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli