PDBe 4zjc

X-ray diffraction
2.83Å resolution

Structures of the human OX1 orexin receptor bound to selective and dual antagonists

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycogen synthase; Orexin receptor type 1 Chain: A
Molecule details ›
Chain: A
Length: 553 amino acids
Theoretical weight: 62.69 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O43613 (Residues: 1-246, 288-380; Coverage: 80%)
  • Canonical: Q9V2J8 (Residues: 218-413; Coverage: 45%)
  • nullnull
Gene names: HCRTR1, PAB2292
Sequence domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P212121
Unit cell:
a: 63.431Å b: 66.466Å c: 182.129Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.216 0.262
Expression system: Spodoptera frugiperda