PDBe 4z6y

X-ray diffraction
2.81Å resolution

Structure of the TBC1D7-TSC1 complex

Released:
Source organism: Homo sapiens
Entry authors: Gai Z, Wu G

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
TBC1 domain family member 7 Chains: A, B, E, G
Molecule details ›
Chains: A, B, E, G
Length: 273 amino acids
Theoretical weight: 31.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9P0N9 (Residues: 21-293; Coverage: 93%)
Gene names: HSPC239, TBC1D7, TBC7
Sequence domains: Rab-GTPase-TBC domain
Structure domains:
Hamartin Chains: C, D, F, H
Molecule details ›
Chains: C, D, F, H
Length: 56 amino acids
Theoretical weight: 6.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92574 (Residues: 938-993; Coverage: 5%)
Gene names: KIAA0243, TSC, TSC1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 56.991Å b: 145.689Å c: 114.758Å
α: 90° β: 89.65° γ: 90°
R-values:
R R work R free
0.209 0.206 0.255
Expression system: Escherichia coli