PDBe 4yyp

X-ray diffraction
2.6Å resolution

Crystal structure of human PLK4-PB3 in complex with STIL-CC


Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
SCL-interrupting locus protein Chain: B
Molecule details ›
Chain: B
Length: 32 amino acids
Theoretical weight: 3.85 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q15468 (Residues: 720-751; Coverage: 3%)
Gene names: SIL, STIL
Serine/threonine-protein kinase PLK4 Chain: A
Molecule details ›
Chain: A
Length: 87 amino acids
Theoretical weight: 9.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: O00444 (Residues: 884-970; Coverage: 9%)
Gene names: PLK4, SAK, STK18
Sequence domains: POLO box duplicated region

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: C2221
Unit cell:
a: 86.57Å b: 136.33Å c: 33.44Å
α: 90° β: 90° γ: 90°
R R work R free
0.221 0.217 0.254
Expression systems:
  • Not provided
  • Escherichia coli BL21(DE3)