PDBe 4yqm

X-ray diffraction
2.38Å resolution

Glutathione S-transferase Omega 1 bound to covalent inhibitor C1-27

Released:

Function and Biology Details

Reactions catalysed:
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate
RX + glutathione = HX + R-S-glutathione
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase omega-1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 244 amino acids
Theoretical weight: 27.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P78417 (Residues: 1-241; Coverage: 100%)
Gene names: GSTO1, GSTTLP28
Sequence domains:
Structure domains: Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: C2
Unit cell:
a: 182.838Å b: 71.247Å c: 61.852Å
α: 90° β: 104.08° γ: 90°
R-values:
R R work R free
0.207 0.205 0.237
Expression system: Escherichia coli