PDBe 4yc7

X-ray diffraction
2.5Å resolution

Crystal structure of human FMNL2 GBD-FH3 Domains bound to Cdc42-GppNHp

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Formin-like protein 2 Chain: B
Molecule details ›
Chain: B
Length: 381 amino acids
Theoretical weight: 44.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96PY5 (Residues: 1-379; Coverage: 35%)
Gene names: FHOD2, FMNL2, KIAA1902
Sequence domains: Diaphanous GTPase-binding Domain
Cell division control protein 42 homolog Chain: A
Molecule details ›
Chain: A
Length: 181 amino acids
Theoretical weight: 20.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P60953 (Residues: 1-179; Coverage: 94%)
  • Best match: P60953-1 (Residues: 1-179)
Gene name: CDC42
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P41212
Unit cell:
a: 91.094Å b: 91.094Å c: 144.275Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.194 0.253
Expression system: Escherichia coli