PDBe 4y6q

X-ray diffraction
1.9Å resolution

Human SIRT2 in complex with 2-O-myristoyl-ADP-ribose

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD-dependent protein deacetylase sirtuin-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 293 amino acids
Theoretical weight: 33.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8IXJ6 (Residues: 52-356; Coverage: 75%)
  • Best match: Q8IXJ6-4 (Residues: 52-270)
Gene names: SIR2L, SIR2L2, SIRT2
Sequence domains: Sir2 family
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P21
Unit cell:
a: 61.186Å b: 142.369Å c: 62.626Å
α: 90° β: 94.41° γ: 90°
R-values:
R R work R free
0.233 0.231 0.267
Expression system: Escherichia coli BL21(DE3)