PDBe 4xyk

X-ray diffraction
3.4Å resolution

Crystal structure of human phosphofructokinase-1 in complex with ADP, Northeast Structural Genomics Consortium Target HR9275


Function and Biology Details

Reaction catalysed:
ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
ATP-dependent 6-phosphofructokinase, platelet type Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 812 amino acids
Theoretical weight: 89.14 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
  • Canonical: Q01813 (Residues: 1-784; Coverage: 100%)
Gene names: PFKF, PFKP
Sequence domains: Phosphofructokinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P21
Unit cell:
a: 79.345Å b: 168.373Å c: 133.272Å
α: 90° β: 103.78° γ: 90°
R R work R free
0.256 0.256 0.29
Expression system: unidentified baculovirus