PDBe 4xyj

X-ray diffraction
3.1Å resolution

Crystal structure of human phosphofructokinase-1 in complex with ATP and Mg, Northeast Structural Genomics Consortium Target HR9275

Released:

Function and Biology Details

Reaction catalysed:
ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-dependent 6-phosphofructokinase, platelet type Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 812 amino acids
Theoretical weight: 89.14 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q01813 (Residues: 1-784; Coverage: 100%)
Gene names: PFKF, PFKP
Sequence domains: Phosphofructokinase

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P21
Unit cell:
a: 137.199Å b: 159.329Å c: 170.533Å
α: 90° β: 104.2° γ: 90°
R-values:
R R work R free
0.221 0.221 0.246
Expression system: unidentified baculovirus