PDBe 4xxd

X-ray diffraction
2.41Å resolution

Crystal Structure of mid-region amyloid beta capture by solanezumab

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin heavy constant gamma 1 Chains: B, E
Molecule details ›
Chains: B, E
Length: 223 amino acids
Theoretical weight: 23.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 1-107; Coverage: 32%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Immunoglobulin kappa constant Chains: A, D
Molecule details ›
Chains: A, D
Length: 219 amino acids
Theoretical weight: 24.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01834 (Residues: 1-107; Coverage: 100%)
Gene name: IGKC
Sequence domains: Immunoglobulin C1-set domain
P3(40) Chains: C, F
Molecule details ›
Chains: C, F
Length: 17 amino acids
Theoretical weight: 1.96 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 683-699; Coverage: 2%)
Gene names: A4, AD1, APP

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P1
Unit cell:
a: 38.796Å b: 73.555Å c: 92.118Å
α: 109.91° β: 93.64° γ: 93.31°
R-values:
R R work R free
0.251 0.249 0.29
Expression systems:
  • Homo sapiens
  • Not provided