› 4xwx

X-ray diffraction
1.87Å resolution

Crystal structure of the PTB domain of SHC

Released:
DOI: 10.2210/pdb4xwx/pdb
PDB entry 4xwx coloured by chain, front view.
PDB entry 4xwx coloured by chain, side view.
PDB entry 4xwx coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chaikuad A, Tallant C, Krojer T, Dixon-Clarke S, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151418 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SHC-transforming protein 1 Chain: A
Molecule details ›
Chain: A
Length: 167 amino acids
Theoretical weight: 18.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29353 (Residues: 147-311; Coverage: 28%)
Gene names: SHC, SHC1, SHCA
Sequence domains: Phosphotyrosine interaction domain (PTB/PID)
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

2 bound ligands:
Ligand EDO 6 x EDO
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2221
Unit cell:
a: 64.91Å b: 126.79Å c: 50.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 0.168 0.191
Expression system: Escherichia coli BL21(DE3)

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