PDBe 4xpn

X-ray diffraction
2.28Å resolution

Crystal Structure of Protein Phosphate 1 complexed with PP1 binding domain of GADD34

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit Chains: A, C
Molecule details ›
Chains: A, C
Length: 299 amino acids
Theoretical weight: 34.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62136 (Residues: 7-300; Coverage: 89%)
Gene names: PPP1A, PPP1CA
Sequence domains:
Structure domains: Purple Acid Phosphatase; chain A, domain 2
Protein phosphatase 1 regulatory subunit 15A Chains: B, D
Molecule details ›
Chains: B, D
Length: 43 amino acids
Theoretical weight: 4.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75807 (Residues: 552-591; Coverage: 6%)
Gene names: GADD34, PPP1R15A

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P212121
Unit cell:
a: 64.311Å b: 112.853Å c: 125.013Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.161 0.159 0.205
Expression system: Escherichia coli