PDBe 4xjj

X-ray diffraction
1.4Å resolution

Extracellular domain of type II Transforming Growth Factor Beta receptor in complex with 2-(2-Hydroxyethyl)NDSB-201

Released:
Source organism: Homo sapiens
Entry authors: Wangkanont K, Forest KT, Kiessling LL

Function and Biology Details

Reaction catalysed:
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. 
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TGF-beta receptor type-2 Chain: A
Molecule details ›
Chain: A
Length: 112 amino acids
Theoretical weight: 12.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37173 (Residues: 50-159; Coverage: 20%)
Gene name: TGFBR2

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P212121
Unit cell:
a: 35.17Å b: 40.373Å c: 76.341Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.154 0.153 0.185
Expression system: Escherichia coli BL21(DE3)