PDBe 4xg8

X-ray diffraction
2.4Å resolution

Crystal structure of an inhibitor-bound Syk


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein kinase SYK Chains: A, C
Molecule details ›
Chains: A, C
Length: 290 amino acids
Theoretical weight: 33.9 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P43405 (Residues: 356-635; Coverage: 44%)
Gene name: SYK
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B1
Spacegroup: P1
Unit cell:
a: 39.964Å b: 42.212Å c: 87.72Å
α: 99.97° β: 90.5° γ: 101.05°
R R work R free
0.249 0.247 0.275
Expression system: Spodoptera frugiperda