PDBe 4xcu

X-ray diffraction
1.71Å resolution

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 4 Chain: A
Molecule details ›
Chain: A
Length: 300 amino acids
Theoretical weight: 33.87 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P22455 (Residues: 449-751; Coverage: 38%)
Gene names: FGFR4, JTK2, TKF
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P21
Unit cell:
a: 39.1Å b: 58.11Å c: 58.67Å
α: 90° β: 94.42° γ: 90°
R-values:
R R work R free
0.196 0.193 0.243
Expression system: Spodoptera frugiperda