PDBe 4x3o

X-ray diffraction
1.5Å resolution

Sirt2 in complex with a myristoyl peptide

Released:
Source organism: Homo sapiens
Entry authors: Wang Y, Zhang WZ, Hao Q

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
NAD-dependent protein deacetylase sirtuin-2 Chain: A
Molecule details ›
Chain: A
Length: 304 amino acids
Theoretical weight: 34.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IXJ6 (Residues: 52-355; Coverage: 78%)
Gene names: SIR2L, SIR2L2, SIRT2
Sequence domains: Sir2 family
Structure domains:
peptide PRO-LYS-LYS-THR-GLY Chain: C
Molecule details ›
Chain: C
Length: 5 amino acids
Theoretical weight: 532 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 37.433Å b: 77.594Å c: 56.249Å
α: 90° β: 97.22° γ: 90°
R-values:
R R work R free
0.123 0.121 0.157
Expression systems:
  • Escherichia coli
  • Not provided