PDBe 4wv6

X-ray diffraction
1.75Å resolution

Heterodimer of Importin alpha 1 with nuclear localization signal of TAF8


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 471 amino acids
Theoretical weight: 50.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P52292 (Residues: 60-529; Coverage: 89%)
Gene names: KPNA2, RCH1, SRP1
Sequence domains:
Structure domains: Leucine-rich Repeat Variant
Transcription initiation factor TFIID subunit 8 Chains: B, C
Molecule details ›
Chains: B, C
Length: 14 amino acids
Theoretical weight: 1.67 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q7Z7C8 (Residues: 297-310; Coverage: 5%)
Gene names: TAF8, TAFII43, TBN

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P212121
Unit cell:
a: 54.27Å b: 77.72Å c: 128.57Å
α: 90° β: 90° γ: 90°
R R work R free
0.155 0.153 0.18
Expression systems:
  • Escherichia coli
  • Not provided