PDBe 4wv1

X-ray diffraction
2.36Å resolution

Crystal structure of the FGFR2 D2 domain in complex with Fab 2B.1.3

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fibroblast growth factor receptor 2 Chains: C, F
Molecule details ›
Chains: C, F
Length: 99 amino acids
Theoretical weight: 11.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21802 (Residues: 153-251; Coverage: 12%)
Gene names: BEK, FGFR2, KGFR, KSAM
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins
Fab heavy chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 230 amino acids
Theoretical weight: 24.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
Fab light chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 214 amino acids
Theoretical weight: 23.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 76.087Å b: 181.239Å c: 94.427Å
α: 90° β: 113.72° γ: 90°
R-values:
R R work R free
0.201 0.198 0.244
Expression system: Escherichia coli