Function and Biology Details
ATP + H(2)O = ADP + phosphate
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position.
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
- not assigned
Structure analysis Details
Length: 326 amino acids
Theoretical weight: 36.16 KDa
Source organism: Betacoronavirus England 1
Expression system: Escherichia coli BL21(DE3)
- Canonical: K9N7C7 (Residues: 1482-1801; Coverage: 5%)