PDBe 4wo0

X-ray diffraction
1.34Å resolution

Crystal structure of transthyretin in complex with apigenin

Released:
Source organism: Homo sapiens
Primary publication:
Structural evidence for asymmetric ligand binding to transthyretin.
Acta Crystallogr. D Biol. Crystallogr. 71 1582-92 (2015)
PMID: 26249340

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21212
Unit cell:
a: 42.66Å b: 85.739Å c: 63.978Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.185 0.206
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'