PDBe 4wa9

X-ray diffraction
2.2Å resolution

The crystal structure of human abl1 wild type kinase domain in complex with axitinib

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 33.04 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00519 (Residues: 246-512; Coverage: 24%)
Gene names: ABL, ABL1, JTK7
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Unit cell:
a: 56.626Å b: 111.806Å c: 128.881Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.173 0.212
Expression system: Spodoptera frugiperda